General Information

  • ID:  hor003058
  • Uniprot ID:  NA
  • Protein name:  Neurotensin
  • Gene name:  NA
  • Organism:  Pelophylax ridibundus
  • Family:  Neurotensin family
  • Source:  Animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  NA
  • GO MF:  NA
  • GO BP:  NA
  • GO CC:  NA

Sequence Information

  • Sequence:  EAHISKARRPYIL
  • Length:  13
  • Propeptide:  NA
  • Signal peptide:  NA
  • Modification:  T1 Pyrrolidone carboxylic acid
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Release lphaMSH from perifused frog pars intermedia cells
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:   NA
  • IC50:  NA
  • EC50:  NA
  • ED50:  5*10(-9) M
  • Kd:  NA
  • Half life:  NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor003058_AF2.pdbhor003058_ESM.pdb

Physical Information

Mass: 176805 Formula: C70H116N22O18
Absent amino acids: CDFGMNQTVW Common amino acids: AIR
pI: 10.45 Basic residues: 4
Polar residues: 2 Hydrophobic residues: 5
Hydrophobicity: -53.08 Boman Index: -3202
Half-Life / Aliphatic Index: 1 hour Aliphatic Index: 105.38
Instability Index: 11019.23 Extinction Coefficient cystines: 1490
Absorbance 280nm: 124.17

Literature

  • PubMed ID:  9751493
  • Title:  Isolation, Primary Structure, and Effects on Alpha-Melanocyte-Stimulating Hormone Release of Frog Neurotensin